New Treatments for Osteoarthritis

New Treatments for Osteoarthritis : Cartilage Regeneration.

New treatments for osteoarthritis may allow to you to do the things you enjoy

This is one of the new treatments for osteoarthritis may, in the future, allow to you to do the things you enjoy!

I seem to be talking about stem cells a lot lately and here they are again. They really do seem to be the most promising of all the new treatments for osteoarthritis.

This generation of new treatments for osteoarthritis have a whole new approach to cartilage degeneration and are at last they are finding ways to make the cartilage grow again. Up to now they have been chasing symptoms rather than curing the actual condition.

A report in Science News says that researchers seem to have found the key that switches on our cartilage to regenerate.  The key is a molecule called kartogenin and although in it’s early stages of research this promises to be one of the best new treatments for osteoarthritis.

“The new approach taps into mesenchymal stem cells, which naturally reside in cartilage and give rise to cells that make connective tissue. These include chondrocytes, the only cells in the body that manufacture cartilage. Kartogenin steers the stem cells to wake up and take on cartilage-making duties. This is an essential step in the cartilage repair that falls behind in people with osteoarthritis, the most common kind of arthritis, which develops from injury or long-term joint use.

In the blue-sky scenario, this would be a locally delivered therapy that would target stem cells already there,” says study coauthor Kristen Johnson, a molecular biologist at the Genomics Institute of the Novartis Research Foundation in San Diego.”

Bring on Stupp and his noodle highways another of the new treatments for osteoarthritis that promises a brighter! Unfortunately this research has only been tested on mice with bad knees so far but this was the result:

“Johnson and her colleagues screened 22,000 compounds in cartilage and found that one, kartogenin, induced stem cells to take on the characteristics of chondrocytes. The molecule turned on genes that make cartilage components called aggrecan and collagen II. Tests of mice with cartilage damage similar to osteoarthritis showed that kartogenin injections lowered levels of a protein called cartilage oligomeric matrix protein. People with osteoarthritis have an excess of the protein, which is considered a marker of disease severity. Kartogenin also enabled mice with knee injuries to regain weight-bearing capacity on the joint within 42 days.

Lab work revealed that kartogenin inhibits a protein called filamin A in the mesenchymal stem cells. This unleashes other compounds that can then orchestrate the activity of genes useful in turning the stem cells into functional chondrocytes. In so doing, Johnson says, kartogenin seems to protect and repair cartilage.”

However don’t get too excited. This is one of many new treatments for osteoarthritis that is still in the research stage so will probably going to take a good few years to filter into general practice. But this is what molecular biologist Mary Goldring of Weill Cornell Medical College in New York says about new treatments for osteoarthritis:

“Our cartilage wasn’t meant to live this long. A cartilage imbalance results from wear and tear, literally, as people age.  Regenerating the cartilage-making process in the body has become a primary goal in orthopedic medicine.”

As I said yesterday I would love to hear from anyone who has had this stem cell treatment or for that matter any other of the new treatments for osteoarthritis. Please leave your story in the comments below and like us on Facebook to get follow ups on new treatments for osteoarthritis for you for any of your family who may be suffering.

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5 Responses to New Treatments for Osteoarthritis

  1. I heard sulpharophane or sulfarophane from broccoli is being test as a disease modifying treatment or preventative for OA, how about pomegrante extract and strontium for OA

    • Dr. Sophie says:

      They are always testing all sorts of compounds but you have to look at the quality of the research to know if it is good advice or not!

  2. dr c Lakshmi kanth . rheumatologist. says:

    What about 1 analgesics 2norcotic type or non norctic .3 nsaids . 4 il1inhibitors like diasarrin .5 nutrazuticals .6. a combo of above all .7 .intra articular steroids . 8 intargicular byluranidases both high & low molecule. 9 enzymd inhibitors metalloproteases like to doxycyclines .10 pararticular nociptive receptor modulators like pregaballin.11 mix compounds like Colchis in , curcumin , vitc , mineral with tracerdlsments ,stroncium . 14 physiotherapy 15 exercises . 16 wt reduction . 17, alternative treatments . I wonder which Rx suits the pt mater of luck 18 psychologist also adds to. list.being practiced in my center in SRC b
    Hyd India. DRC Lakshmi kanth.I

    • Dr. Sophie says:

      Hi, I have given my opinion on most of these in my article. You can use the search button to find them. Here is a quick overview.
      1. Analgesics- useful but lose their effectiveness over time. They also only mask the pain and don’t reduce the amount of pain suffered.
      2. Narcotic- seriously you want to become an addict and non narcotic are simply pretty ineffective!
      3. NSAIDs- dangerous taken in the long term due to the side effects.
      4. Il 1 inhibitors like diasarrin- unprovem for OA
      5. nutrazuticals= I assume you mean naturacuticals such as supplements- I have lots on this on this site.
      6. A combo of the above- read my book!
      7. Intra articular steroids- hardly natural and only last a couple of months at best!
      8. intargicular hyaluronidases both high & low molecule- again lots on this site and as far as I am concerned the jury is still out on their effectiveness.
      9, 10 and 11- you are reaching here as the research is poor to support it’s use to say the least.
      14. and onwards! Physiotherapy- what do you think all my treatment is based on? Look at the name of the site!

      What I do is try and help people to help themselves rather than become dependant on people who can’t cure them which you can’t!

  3. Bill says:

    As an OA suffer, it’s not only the pain that is present, it interferes with physical actives. This cause many people to become sedentary. I do my best to ignore the pain and remain active. As active as I am, the OA has slowed me down, thus I gain weight even though I am a healthy eater.
    I have tried all the snake oil treatments, but I realize it only masks the pain and does not heal the joints affected.
    At age 71 I doubt there will be any cures in my lifetime, but I hope that research will find a cure for our future generations. My greatest fear is living a long life but a lesser quality of life. I certainly don’t want to be pushing a walker around an Assisted Living Facility.

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