Side Effects of NSAIDs for Osteoarthritis Sufferers

Side Effects of NSAIDs

You need to discuss the side effects of NSAIDs with your Doctor when you are taking them for the long term.

There has been a major new study published in the Lancet about the side effects of NSAIDs. It has collated information from 280 other studies and this sort of study, known as meta-analyses, is generally considered the best type of research.

It is very important you read this if you are taking medication such as ibuprofen and diclofencac, or a COX-2 inhibitor such as Celebrex as the study found some disturbing side effects of NSAIDs for long term users such as OA sufferers.

The Study

The study went back over other trials and put all the data together. They included 280 trials of NSAIDs versus placebo and 474 trials of one NSAID versus another NSAID. That means 353,809 people were studied in total, making this, I believe, the largest study ever carried out on NSAIDs.


  • Major vascular events were increased by about a third by a coxib or diclofenac chiefly due to an increase in major coronary events.
  • Ibuprofen also significantly increased major coronary events.
  • Compared with placebo, of 1000 patients allocated to a coxib or diclofenac for a year, three more had major vascular events, one of which was fatal.
  • Naproxen did not significantly increase major vascular events.
  • Vascular death was increased significantly by coxibs and diclofenac, non-significantly by ibuprofen, but not by naproxen.
  • The proportional effects on major vascular events were independent of baseline characteristics, including vascular risk.
  • Heart failure risk was roughly doubled by all NSAIDs.
  • All NSAID regimens increased upper gastrointestinal complications.

What This Means For You

To put it in  nutshell if you are in a high risk category for a heart attack or vascular disease you are doubling the chance of a heart attack or vascular incident such as a stroke. You need to look at alternative ways of controlling the inflammation.

How To Stop the Side Effects of NSAIDs

Click on this link describing what osteoarthritis is and where the inflammation comes from. OA is a non-inflammatory arthritis but there is inflammation which from the soft tissue (the muscles, tendons and ligaments) around the joint. There are alternative, natural ways to control this inflammation.

If you want to find out more about ways to control your inflammation but without increasing your risk of heart failure, heart attack, stroke or ulcers please sign up for my free three day course. It will outline alternatives which are proven to reduce inflammation without the side effects of NSAIDs.

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2 Responses to Side Effects of NSAIDs for Osteoarthritis Sufferers

  1. Attempted to sign up for your free three day course regarding alternatives to reduce inflammation without the side effects of NSAIDs but was unable to do so. Site not available.

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